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KMID : 1098420160240010014
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Korean Journal of Medicinal Crop Science
2016 Volume.24 No. 1 p.14 ~ p.20
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Antioxidant and Antiproliferative Activity of Extracts from Water Chestnut (Trapa japonica Flerow)
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Han Hye-Min
Kwon Yong-Soo
Kim Myong-Jo
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Abstract
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Background : This study aimed to investigate the antioxidant and antiproliferative activities of extract from different parts of water chestnut (Trapa japonica Flerow).
Methods and Results : The total polyphenol content of pericarp and seed extract was 438.31 ㎎/g and 25.32 ㎎/g respectively. DPPH radical scavenging assay showed that the half maximal inhibitory concentration (IC50 values) of pericarp and seed extract were 5.28 ㎍/㎖ and 355.51 ㎍/㎖ respectively. In addition, the pericarp extract showed strong reducing power. In the MTT assay, the pericarp extract significantly inhibited the viability of A549, AGS, HeLa, PC-3, HCT116, HT29 and SW620 cell lines compared with the seed extract.
Conclusions : These results suggest that T. japonica Flerow extracts have significant antioxidant and antiproliferative activity.
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KEYWORD
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Trapa Japonica Flerow, Antioxidant, Antiproliferative, Cancer
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